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amiloride-sensitive Na+ channel subunit gamma; epithelial Na+ channel subunit gamma; gamma-ENaC; SCNEG; nonvoltage-gated Na+ channel 1 subunit gamma; gamma-NaCH (SCNN1G)
Function:
- Na+ permeable non-voltage-sensitive ion channel gamma subunit
- phosphorylated on Ser & Thr
- ubiquitination targets individual subnits for endocytosis & proteasome-mediated degradation (putative)
- interacts with the WW domains of NEDD4, NEDD4L, WWP1 & WWP2
Structure:
- belongs to the amiloride-sensitive Na+ channel family
Compartment:
- apical cell membrane; multi-pass membrane protein
- apical membrane of epithelial cells
Pathology:
- defects in SCNN1G are a cause of Liddle syndrome
General
amiloride sensitive Na+ channel subunit
transmembrane 2 protein
Properties
SIZE: entity length = 649 aa
MW = 74 kD
COMPARTMENT: cellular membrane
MOTIF: cytoplasmic domain {1-55}
transmembrane domain {56-76}
exoplasmic loop {77-541}
MOTIF: N-glycosylation site {N209}
N-glycosylation site {N248}
N-glycosylation site {N271}
N-glycosylation site {N291}
N-glycosylation site {N497}
transmembrane domain {542-562}
cytoplasmic domain {563-649}
Database Correlations
OMIM correlations
UniProt P51170
Pfam PF00858
Entrez Gene 6340
Kegg hsa:6340
References
- UniProt :accession P51170
- GeneReviews
https://www.genecards.org/cgi-bin/carddisp.pl?gene=SCNN1G
Component-of
amiloride-sensitive Na+ channel or lung Na+ channel