Search
Selenocysteine lyase (hSCL, SCLY, SCL)
Function:
- catalyzes decomposition of L-selenocysteine to L-alanine & elemental selenium (putative)
L-selenocysteine + reduced acceptor
selenide + L-alanine + acceptor
Cofactor: pyridoxal phosphate (putative)
Structure:
- homodimer (putative)
- belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family
Compartment: cytoplasm (putative)
Alternative splicing: named isoforms=2
Expression: regulated by AP1
Pathology:
- up-regulated in acute glomerulonephritis
General
lyase
Properties
SIZE: entity length = 445 aa
MW = 48 kD
COMPARTMENT: cytoplasm
MOTIF: cofactor-binding site [259-259]
FOR-BINDING-OF: pyridoxal phosphate
cysteine residue {C388}
Database Correlations
UniProt Q96I15
Pfam PF00266
Kegg hsa:5154
ENZYME 4.4.1.16
References
UniProt :accession Q96I15