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morpheaform or sclerosing basal cell carcinoma
Infiltrating form of BCC with an excessive amount of fibrous stroma appearing as a scar.
Epidemiology: 4-17% of basal cell carcinomas
Pathology:
- clinically more aggressive form of basal cell carcinoma
- micronudular, infiltrative skin neoplasm
Clinical manifestations:
1) flat, indurated, whiteish macules with ill-defined borders
2) pigmentation & telangiectasias may be seen
3) finger-like extensions of tumor often extend far into surrounding tissue, neccessitating wide surgical margins
4) lesions often resemble a scar, but without history of previous trauma to that area
5) lesions generally do not ulcerate until late
Differential diagnosis:
1) cicatrix (scar)
2) localized scleroderma
3) morphea
Database Correlations
OMIM 605462
References
- Color Atlas and Synopsis of Clinical Dermatology, Common
and Serious Diseases, 3rd ed, Fitzpatrick et al, McGraw Hill, NY,
1997, pg 214-17
- Medical Knowledge Self Assessment Program (MKSAP) 11, 16
American College of Physicians, Philadelphia 1998, 2012