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Scl-70 antigen

Spontaneous degradation product of topoisomerase I. Pathology: - antibodies against Scl present in 20-50% of patients with diffuse scleroderma - Scl-70 antigen displays a punctate distribution within the nucleus

Related

Scl-70 (anti-topoisomerase) Ab in serum scleroderma (diffuse cutaneous systemic sclerosis) topoisomerase-1 (TOP1)

General

antigen protein degradation product

Properties

SIZE: MW = 70 kD

References

  1. Clinical Diagnosis & Management by Laboratory Methods, 19th edition, J.B. Henry (ed), W.B. Saunders Co., Philadelphia, PA. 1996, pg 1019
  2. Medical Knowledge Self Assessment Program (MKSAP) 11, American College of Physicians, Philadelphia 1998