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secretogranin-3; secretogranin III; SgIII (SCG3)

Function: - interacts with CHGA (putative) Compartment: - secreted - neuroendocrine & endocrine secretory granules - associated with secretory granule membrane via binding to cholesterol-enriched lipid rafts Alternative splicing: named isoforms=2 Expression: - expressed in brain, heart, kidney, liver, skeletal muscle Polymorphism: - polymorphisms in the 5'-flanking region & in intron 1 may have an effect on transcriptional activity & be associated with an increase in subcutaneous, but not visceral, fat area - hence, may influence the risk of obesity

Related

gene

General

chromogranin; secretogranin;granin

Properties

SIZE: entity length = 468 aa MW = 53 kD COMPARTMENT: cytoplasm MOTIF: signal sequence {1-19} acidic region MOTIF: acidic residue (SEVERAL) cysteine residue {X} MODIFICATION: cysteine residue {C-TERMINAL} cysteine residue {C-TERMINAL} MODIFICATION: cysteine residue {X} MISC-INFO: ISOELECTIC_POINT 5.1

Database Correlations

UniProt Q8WXD2

References

  1. UniProt :accession Q8WXD2
  2. Huttner WB, Gerdes HH, Rosa P. The granin (chromogranin/secretogranin) family. Trends Biochem Sci. 1991 Jan;16(1):27-30. Review. PMID: 2053134