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SCF-type E3 ligase complex
Function:
- mediates ubiquitination & subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction & transcription
Structure:
- subunits include: SKP1, RBX1, CUL1
Related
E3 ubiquitin ligase; ubiquitin-ligating enzyme E3; N end-recognizing protein
Specific
SCF(NIPA) E3 ligase complex
SKP1-CUL1-F-box protein (SCF) complex; SCF(FBXW11) E3 ligase complex; CF(SKP2) E3 ligase complex
General
molecular complex