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myotubularin-related protein 5; SET-binding factor 1; Sbf1 (SBF1, MTMR5)
Function:
- probable pseudophosphatase
- lacks several amino acids in the catalytic pocket which renders it catalytically inactive as a phosphatase
- the pocket is however sufficiently preserved to bind phosphorylated substrates, & maybe protect them from phosphatases
- inhibits myoblast differentiation in vitro & induces oncogenic transformation in fibroblasts
- interacts with the SET domain of MLL/HRX
- interacts with SUV39H1
Structure:
- belongs to the protein-tyrosine phosphatase family non-receptor class myotubularin subfamily
- contains 1 dDENN domain
- contains 1 DENN domain
- contains 1 GRAM domain
- contains 1 myotubularin phosphatase domain
- contains 1 PH domain
- contains 1 uDENN domain
Compartment: nucleus
Alternative splicing: named isoforms=2
General
myotubularin family protein
Properties
SIZE: entity length = 1867 aa
MW = 208 kD
COMPARTMENT: cell nucleus
STATE: active state
MOTIF: uDENN {1-92}
DENN {128-310}
dDENN {363-432}
GRAM {880-968}
Myotubularin phosphatase {1120-1596}
MOTIF: Thr phosphorylation site {T1137}
Thr phosphorylation site {T1749}
PH domain {1761-1865}
Database Correlations
OMIM 603560
UniProt O95248
PFAM correlations
Entrez Gene 6305
Kegg hsa:6305
References
UniProt :accession O95248