salvador homolog 1 protein (45 kD WW domain protein, hWW45, SAV1, WW45)

Function: - scaffold protein - phosphorylated by STK3 & STK4 - phosphorylation is not required for SAV1 stability, but may increase the number of protein binding sites Structure: - homodimer, stabilized through interaction with STK3 or STK4 - contains 1 SARAH domain - contains 2 WW domains Expression: - ubiquitously expressed in adult tissues - highest expression in the pancreas, aorta & interventricular septum - lowest expression in skeletal muscle - expression higher in fetal than in adult heart

General

phosphoprotein scaffold protein

Properties

SIZE: MW = 45 kD entity length = 383 aa COMPARTMENT: synaptic membrane CELL: neuron MOTIF: WW domain (W/rsp5/WWP domain) {199-232} WW domain (W/rsp5/WWP domain) {234-267} SARAH {321-368} coiled coil {344-373}

Database Correlations

OMIM 607203 UniProt Q9H4B6 Pfam PF00397

References

UniProt :accession Q9H4B6