squamous cell carcinoma antigen recognized by T-cells 3 (SART-3, hSART-3, Tat-interacting protein of 110 kD, Tip110, SART3, KIAA0156, TIP110)

Function: 1) regulates Tat transactivation activity through direct interaction Structure: - contains 8 HAT repeats - contains 2 RRM domains (RNA recognition motif) Compartment: cytoplasm, nuclear speckle Alternative splicing: named isoforms=3 Expression: - ubiquitously expressed - expressed in the cytoplasm of all proliferating cells Pathology: 1) interacts with HIV-1 Tat protein 2) cellular factor for HIV-1 gene expression & viral replication (putative) 3) expressed in the nucleus of malignant tumor cell lines & majority of cancer tissues with various histologies, including squamous cell carcinomas (SCC), adenocarcinomas, melanomas & leukemias - undetectable in the nucleus of any cell lines of nonmalignant cells or normal tissues, except for testis - also expressed in cytoplasm of malignant cells

Properties

SIZE: MW = 110 kD entity length = 963 aa COMPARTMENT: cytoplasm cell nucleus MOTIF: coiled coil {21-46} coiled coil {82-110} MOTIF: glutamate-rich region {89-92} MOTIF: glutamate residue (SEVERAL) HAT {126-158} HAT {164-195} HAT {201-237} HAT {242-275} HAT {324-356} HAT {359-391} NAME :SITE RANGE :LOW 394 :HIGH 430 :NAME "HAT" HAT {487-520} coiled coil {559-619} nuclear localization {600-670} MOTIF: nuclear translocation signal {601-617} lysine-rich region {612-616} MOTIF: lysine residue (SEVERAL) RNP motif NAME: RNP motif SITE: 704-782 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif RNP motif NAME: RNP motif SITE: 801-878 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif

Database Correlations

UniProt Q15020 PFAM correlations

References

UniProt :accession Q15020