sterile alpha & TIR motif-containing protein 1; sterile alpha & armadillo repeat protein; sterile alpha motif domain-containing protein 2; SAM domain-containing protein 2; Tir-1 homolog (SARM1, KIAA0524, SAMD2, SARM)

Function: - innate immnune response (putative) - does NOT act in Toll-like receptor signaling pathway - acts as a negative regulator of TICAM1/TRIF-dependent Toll-like receptor signaling by inhibiting induction of TLR3- & TLR4-dependent genes - specifically blocks TICAM1/TRIF-dependent transcription-factor activation & gene induction, without affecting the MYD88- dependent pathway or non-TLR signaling - negative regulator of NF-kappa-B & IRF activation - interacts with & interferes with TICAM1/TRIF function Structure: - contains 2 SAM (sterile alpha motif) domains - contains 1 TIR domain Compartment: cytoplasm Alternative splicing: named isoforms=2 Expression: expressed in kidney, liver > placenta

Properties

SIZE: MW = 79 kD entity length = 724 aa MOTIF: sterile alpha motif NAME: sterile alpha motif SITE: 412-476 sterile alpha motif NAME: sterile alpha motif SITE: 486-548 TIR domain {559-657}

Database Correlations

OMIM 607732 UniProt Q6SZW1 PFAM correlations Entrez Gene 23098 Kegg hsa:23098

References

UniProt :accession Q6SZW1