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sarcospan; K-ras oncogene-associated protein; Kirsten-ras-associated protein (SSPN, KRAG)
Function:
- component of the dystrophin-glycoprotein complex (DGC), a complex that spans the muscle plasma membrane & forms a link between the F-actin cytoskeleton & the extracellular matrix
- preferentially associates with the sarcoglycan subcomplex of the DGC
Compartment:
- cell membrane; multi-pass membrane protein (putative)
- sarcolemma
- cell junction, synapse, postsynaptic cell membrane
- found in myotendinous junctions & in postsynaptic membrane of neuromuscular junctions
- sarcospan is lost in patients with complete or partial loss of sarcoglycans
- possibly the complete, tetrameric sarcoglycan complex is necessary for membrane targeting & localization of sarcospan
Alternative splicing:
- named isoforms=2
Expression:
- isoform 1 is expressed exclusively in heart & skeletal muscle
- isoform 2 is expressed in heart, skeletal muscle, thymus, prostate, testis, ovary, small intestine, colon & spleen
General
human longevity protein
transmembrane 4 protein
Properties
SIZE: entity length = 243 aa
MW = 27 kD
COMPARTMENT: cellular membrane
MOTIF: cytoplasmic domain {1-53}
transmembrane domain {54-74}
exoplasmic loop {75-86}
transmembrane domain {87-107}
cytoplasmic loop {108-122}
transmembrane domain {123-143}
exoplasmic loop {144-193}
transmembrane domain {194-214}
cytoplasmic domain {215-243}
Database Correlations
OMIM 601599
UniProt Q14714
Pfam PF04103
Entrez Gene 8082
Kegg hsa:8082
References
- UniProt :accession Q14714
- OMIM :accession 601599
- Entrez Gene :accession 8082
Component-of
dystrophin associated protein complex (DPC)