sarcomeric/mitochondrial creatine kinase (S-mtCK, CKMT2)

Function: - reversibly catalyzes transfer of phosphate between ATP & various phosphogens (e.g. creatine phosphate) - creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain & spermatozoa - binds cardiolipin ATP + creatine = ADP + phosphocreatine Structure: - octamer composed of four CKMT2 homodimers - belongs to the ATP:guanido phosphotransferase family Compartment: - mitochondrial inner membrane; intermembrane side Expression: - sarcomere-specific - found only in heart & skeletal muscles

General

creatine kinase mitochondrial membrane protein

Properties

SIZE: entity length = 419 aa MW = 48 kD COMPARTMENT: mitochondrial inner membrane (GO:0005743) MOTIF: binding site SITE: 40-64 FOR-BINDING-OF: cardiolipin ATP-binding site NAME: ATP-binding site SITE: 162-166 ATP-binding site NAME: ATP-binding site SITE: 225-225 cysteine residue {C317} ATP-binding site NAME: ATP-binding site SITE: 326-326 ATP-binding site NAME: ATP-binding site SITE: 354-359 ATP-binding site NAME: ATP-binding site SITE: 369-369 SUBUNITS: creatine kinase M subunit MOTIF: ATP-binding site NAME: ATP-binding site SITE: 128-132 ATP-binding site NAME: ATP-binding site SITE: 191-191 cysteine residue {C283} ATP-binding site NAME: ATP-binding site SITE: 292-292 ATP-binding site NAME: ATP-binding site SITE: 320-325 ATP-binding site NAME: ATP-binding site SITE: 335-335 creatine kinase B subunit MOTIF: Tyr phosphorylation site {Y39} Tyr phosphorylation site {Y125} ATP-binding site NAME: ATP-binding site SITE: 128-132 Ser phosphorylation site {S164} ATP-binding site NAME: ATP-binding site SITE: 191-191 cysteine residue {C283} ATP-binding site NAME: ATP-binding site SITE: 292-292 ATP-binding site NAME: ATP-binding site SITE: 320-325 ATP-binding site NAME: ATP-binding site SITE: 335-335

Database Correlations

OMIM 123295 UniProt P17540 PFAM correlations Kegg hsa:1160 ENZYME 2.7.3.2

References

UniProt :accession P17540

Components

creatine kinase B subunit (CKB) creatine kinase M subunit (CKM)