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NET proto-oncogene protein; ETS domain-containing protein Elk-3; ETS-related protein NET; ETS-related protein ERP; SRF accessory protein 2; SAP-2 (ELK3, NET, SAP2)
Function:
- may be a negative regulator of transcription, but can activate transcription when coexpressed with Ras, Src or mos
- forms a ternary complex with the serum response factor & the ETS & SRF motifs of the Fos serum response element
- interacts with CTBP1
Structure:
- belongs to the ETS family
- contains 1 ETS DNA-binding domain
Compartment: nucleus
General
Ets family protein
Properties
SIZE: entity length = 407 aa
MW = 44 kD
COMPARTMENT: cell nucleus
MOTIF: ETS domain
NAME: ETS domain
SITE: 5-85
alanine-rich region {207-212}
MOTIF: alanine residue (SEVERAL)
Ser phosphorylation site {S245}
CTBP-binding {273-277}
Database Correlations
OMIM 600247
UniProt P41970
Pfam PF00178
Entrez Gene 2004
Kegg hsa:2004
References
UniProt :accession P41970