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trospium; trospium chloride (Sanctura, Spasmoplex, Spasmex, Relaspium)

Tradenames: Sanctura Indications: - urinary urgency, urinary frequency due to overactive bladder, urge incontinence Contraindications: 1) patients with GI motility problems 2) myasthenia gravis 3) ulcerative colitis Dosage: - 20 mg PO BID on an empty stomach - Sanctura XR: 60 mg PO QD [4] Pharmacokinetics: 1) not metabolized 2) does not cross blood brain barrier Adverse effects: 1) gastroparesis 2) lower incidence of dry mouth than oxybutinin [3] Drug interactions: -> no cyt P450 interactions [2] Mechanism of action: 1) primarily antagonizes muscarinic M2 & M3 receptors 2) inhibits bladder contraction & urge to void

Interactions

drug interactions drug adverse effects of parasympatholytics

General

urinary antispasmodic

Properties

Database Correlations

PUBCHEM correlations

References

  1. Prescriber's Letter 11(9): 2004 Detail-Document#: 200910 (subscription needed) http://www.prescribersletter.com
  2. Prescriber's Letter 12(2): 2005 Antimuscarinic Medications for Overactive Bladder Detail-Document#: 210209 (subscription needed) http://www.prescribersletter.com
  3. Erdem M & Chu FM Management of overactive bladder and urge urinary incontinence in the elderly patient. Am J Med 2006;119(3A):295
  4. Prescriber's Letter 15(1): 2008 New Dosage Form: Sanctura XR (Trospium Extended-Release) Detail-Document#: 240108 (subscription needed) http://www.prescribersletter.com
  5. Medscape. trospium chloride (Rx) https://reference.medscape.com/drug/sanctura-trospium-chloride-342881

Component-of

trospium; trospium chloride (Sanctura, Spasmoplex, Spasmex, Relaspium)

Components

trospium; trospium chloride (Sanctura, Spasmoplex, Spasmex, Relaspium)