Search
SAM domain & HD domain-containing protein 1; dendritic cell-derived IFNG-induced protein; monocyte protein 5 (DCIP,MOP-5, SAMHD1, MOP5)
Structure:
- contains 1 HD domain
- contains 1 SAM domain (sterile alpha motif)
Expression:
- expressed in heart, skeletal muscle, spleen, liver, small intestine, placenta, lung, peripheral blood leukocytes
- no expression in brain or thymus
- induced by interferon gamma
Genetics:
- SAMHD1 variants are associated with extended reproductive lifespan in women & increased all-cause cancer risk in both men & women
- cancers include prostate cancer in men, mesothelioma in both men & women, & suggestive evidence for higher breast cancer susceptibility in women [2]
- average age of natural menopause extended 1.35 years
General
other protein
Properties
SIZE: MW = 72 kD
entity length = 626 aa
MOTIF: acetylation site
SITE: 1-1
EFFECTOR-BOUND: acetyl
sterile alpha motif
NAME: sterile alpha motif
SITE: 45-110
HD {164-319}
Database Correlations
OMIM 606754
MORBIDMAP 606754
UniProt Q9Y3Z3
PFAM correlations
References
- UniProt :accession Q9Y3Z3
- Stankovic S, Shekari S, Huang QQ et al
Genetic links between ovarian ageing, cancer risk and de novo mutation rates.
Nature. 2024 Sep 11.
PMID: 39261734
https://www.nature.com/articles/s41586-024-07931-x