Search
salivary gland pleiomorphic adenoma
Epidemiology:
- most common tumor of the salivary gland
- usually diagnosed in children
Pathology:
- benign epithelial tumor
- results from transformation of adipocytes
Genetics:
- chromosomal translocation t(3;8)(p21;q12) involving PLAG1 with constitutively expressed beta-catenin/CTNNB1
- chromosomal translocation t(3;8)(p21;q12) involving PLAG1 with TCEA1
- chromosomal translocation t(5;8)(p13;q12) involving PLAG1 with LIFR
- ectopic expression of PLAG1 under the control of promoters of distinct translocation partner genes is a general pathogenetic mechanism for pleiomorphic adenomas with 8q aberrations
- chromosomal translocation t(7;8)(p22;q13) involving COL1A2 with PLAG1 may be a cause of lipoblastoma
General
adenoma
Database Correlations
OMIM correlations
References
- UniProt :accession Q6DJT9
- UniProt :accession P08123