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salicylate
ortho-hydroxybenzoate.
Dosage:
- estimated lethal dose is 15 g
Pharmacokinetics:
- major hydrolysis product of aspirin
Adverse effects:
1) tinnitius, inhibits outer hair cell motility
2) stomach upset
3) leukopenia (uncommon)
4) thrombocytopenia (uncommon)
Laboratory:
1) specimen: serum, plasma (EDTA), urine
2) methods:
a) serum/plasma: HPLC, GLC, color, fluorometry, FPIA, EIA
b) urine: EIA
3) interferences:
a) colorimetric & fluorometric assays subject to multiple interference; however, they are fast & useful for emergency overdose assessment
b) diflusinal interferes with FPIA & color methods
c) lipemic, icteric, or hemolyzed specimens may give false positive results with color method
4) labs with Loincs
- salicylate in specimen
- salicylate in body fluid
- salicylate in gastric fluid
- salicylate in blood
- salicylate in serum/plasma
- salicylate in urine
Mechanism of action:
1) non-acetylated salicylates are
a) more potent inhibitors of cyclo-oxygenase-2 (COX-2) than COX-1
b) they differ from aspirin & NSAIDs with regards to
1] diminished propensity to induce peptic ulcer disease
2] no interference with renal blood flow
3] no inhibition of platelet function
2) since anti-inflammatory properties are due to COX-2 inhibition, non-acetylated salicylates are good anti-inflammatory agents
3) inhibitor of outer hair cell motility
- competitive antagonist at SLC26A5 (prestin) anion-binding site
Interactions
drug interactions
drug adverse effects of NSAIDs
monitor with non steroidal anti-inflammatory agents (NSIADs)
Related
bismuth subsalicylate (Pepto-Bismol, BSS, Kaopectate)
salicylate in serum/plasma
salicylate toxicity
Specific
5-aminosalicylate (5-ASA)
aminosalicylate; aminosalicylic acid
aspirin (Ecotrin, Empirin, Bayer aspirin, Vazalore, ASA)
choline salicylate
magnesium salicylate
methyl salicylate
phenyl salicylate
salicylic acid
salsalate (Salflex, Disalcid, sasapyrine)
thiosalicylate
General
benzoate
non-steroidal anti-inflammatory agent (NSAID)
Properties
INHIBITS: cyclooxygenase
MISC-INFO: 1/2life 2.4-3.0 HOURS
therapeutic-range <100 UG/ML
150-300 UG/ML
toxic-range >150 NG/ML
>150 NG/ML
>250 NG/ML
>500 NG/ML
protein-binding 90-95% << 100 ug/mL>
50% <400 ug/mL>
Database Correlations
PUBCHEM correlations
References
- Mayo Internal Medicine Board Review, 1998-99, Prakash UBS (ed)
Lippincott-Raven, Philadelphia, 1998, pg 853-54, 763
- Clinical Guide to Laboratory Tests, 3rd ed. Teitz ed.,
W.B. Saunders, 1995
- Department of Veterans Affairs, VA National Formulary
- Medical Knowledge Self Assessment Program (MKSAP) 15,
American College of Physicians, Philadelphia 2009
- The Washington Manual of Medical Therapeutics, 33rd edition
Foster C et al (eds)
Lippincott, Williams & Wilkins, Philadelphia, 2010, pg 945
Component-of
acetaminophen/caffeine/salicylate
acetaminophen/codeine/salicylate
alpha tocopherol/menthol/nonivamide/salicylate
caffeine/codeine/pheniramine/phenylephrine/salicylate
caffeine/pheniramine/phenylephrine/salicylate
caffeine/salicylate
capsaicin/lidocaine/salicylate
capsaicin/salicylate
choline/salicylate
dextromethorphan/lidocaine/salicylate
diphenhydramine/salicylate
hyoscyamine/methenamine/methylene blue/phenyl salicylate/salicylate/sodium phosphate
hyoscyamine/methenamine/methylene blue/salicylate
hyoscyamine/methenamine/methylene blue/salicylate/sodium phosphate
methenamine/salicylate
Occlusal-HP (salicylic acid 17%)
SalAc (salicylic acid 2%)
trilisate (choline magnesium trisalicylate)
willow bark