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sacubitril
Indications:
- used in combination with valsartan for treatment of heart failure
Contraindications:
- sacubitril is contraindicated in patients with a history of angioedema [3]
Mechanism of action:
- inhibits neprilysin
General
neprilysin inhibitor
References
- McMurray JJV et al.
Angiotensin-neprilysin inhibition versus enalapril in heart
failure.
N Engl J Med 2014 Aug 30;
PMID: 25176015
http://www.nejm.org/doi/full/10.1056/NEJMoa1409077
- FDA News Release. July 7, 2015
FDA approves new drug to treat heart failure
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm453845.htm
- Medical Knowledge Self Assessment Program (MKSAP) 20
American College of Physicians, Philadelphia 2025
Component-of
sacubitril/valsartan (Entresto)