A-kinase anchor protein 1, mitochondrial; A-kinase anchor protein 149 kD; AKAP 149; dual specificity A-kinase-anchoring protein 1; D-AKAP-1; protein kinase A-anchoring protein 1; PRKA1; spermatid A-kinase anchor protein 84; S-AKAP84 (AKAP1, AKAP149, PRKA1)

Function: - binds to type I & II regulatory subunits of protein kinase A & anchors them to the cytoplasmic face of the mitochondrial outer membrane Structure: - RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the PKA-R-subunit dimer - contains 1 KH domain - contains 1 Tudor domain Compartment: mitochondrial outer membrane (putative) Alternative splicing: - named isoforms=2 - at least one isoform may be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay Expression: - AKAP149 is highly expressed in prostate & small intestine - S-AKAP84 is expressed in kidney, pancreas, liver, lung & brain - AKAP149 is also expressed in colon carcinoma

General

A-kinase anchor protein mitochondrial protein phosphoprotein RNA-binding protein

Properties

SIZE: entity length = 903 aa MW = 97 kD COMPARTMENT: mitochondria MOTIF: Thr phosphorylation site {T70} Ser phosphorylation site {S105} Ser phosphorylation site {S107} Ser phosphorylation site {S151} Ser phosphorylation site {S169} PKA-RII subunit binding {344-357} Ser phosphorylation site {S429} Thr phosphorylation site {T533} KH domain SITE: 607-671 FOR-BINDING-OF: ribonucleic acid Tudor domain SITE: 758-817

Database Correlations

OMIM 602449 UniProt Q92667 PFAM correlations Entrez Gene 8165 Kegg hsa:8165

References

UniProt :accession Q92667