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S100 Ca+2-binding protein
Structure:
- occurs as dimer of two alpha, two beta or one alpha & one beta subunit(s)
Compartment: found in nucleus & cytoplasm.
Expression:
- melanocytes
- breast
- myoepithelial cells
- microglandular adenosis
- sclerosing adenosis, tubular carcinoma: -
- ductal carcinoma: 46% +
Pathology:
- found in:
- melanoma
- clear cell sarcoma
- gliomas
- peripheral nerve sheath tumors
- chordoma
- Langerhans cell lesions
- chondrosarcoma
- liposarcoma - lipoblasts
- GIST: 10-20% +
- gastric adenocarcinoma: 20% +, < 25% of cells
- granular cell tumors
Laboratory: widely used for immunohistochemistry analyses
Interactions
molecular events
Related
protein S100-P; S100 Ca+2-binding protein P (S100P S100E)
S-100 Ag in tissue
S100 Ca+2-binding protein A
General
Ca+2 binding protein
multisubunit protein
Properties
SUBUNITS: protein S100-A1
MOTIF: EF hand
SITE: 13-48
MOTIF: Ca+2-binding site
SITE: 20-33
EF hand
SITE: 50-85
MOTIF: Ca+2-binding site
SITE: 63-74
protein S100-B
MOTIF: EF hand
SITE: 13-48
MOTIF: Ca+2-binding site
SITE: 19-32
EF hand
SITE: 49-84
MOTIF: Ca+2-binding site
SITE: 62-73
References
- Dabbs. Diagnostic Immunohistochemistry. Churchill Livingstone.
2002
Component-of
molecular complex
Components
protein S100-A1; S100 Ca+2-binding protein A1; S-100 protein subunit alpha; S-100 protein alpha chain (S100A1, S100A)
protein S100-B; S100 Ca+2-binding protein B; S-100 protein subunit beta; S-100 protein beta chain (S100B)