ribosomal S6 kinase-3 (ribosomal protein S6 kinase alpha 2, S6K-alpha 2, 90 kD ribosomal protein S6 kinase 2, p90-RSK 3, RSK-3, pp90RSK3, RPS6KA2)

Function: - serine/threonine kinase - may play a role in mediating the growth-factor & stress induced activation of the transcription factor CREB - forms a complex with either ERK1 or ERK2 in quiescent cells - transiently dissociates following mitogenic stimulation - activated by multiple phosphorylations on Thr & Ser (putative) - autophosphorylated on Ser-377, as part of the activation process (putative) Cofactor: Mg⁺² Structure: - belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family, S6 kinase subfamily - contains 1 AGC-kinase C-terminal domain - contains 2 protein kinase domains Compartment: nucleus Alternative splicing: named isoforms=2 Expression: - expressed in many tissues - highest expression in lung & skeletal muscle

Properties

SIZE: entity length = 733 aa MW = 83 kD COMPARTMENT: cell nucleus STATE: active state MOTIF: kinase domain SITE: 59-318 MOTIF: ATP-binding site NAME: ATP-binding site SITE: 65-73 ATP-binding site NAME: ATP-binding site SITE: 91-91 aspartate residue {D184} Ser phosphorylation site {S218} AGC-kinase C-terminal {319-388} MOTIF: Thr phosphorylation site {T356} Ser phosphorylation site {S360} Ser phosphorylation site {S377} kinase domain SITE: 415-672 MOTIF: ATP-binding site NAME: ATP-binding site SITE: 421-429 ATP-binding site NAME: ATP-binding site SITE: 444-444 aspartate residue {D532} Thr phosphorylation site {T570} Ser phosphorylation site {S730}

Database Correlations

OMIM 601685 UniProt Q15349 PFAM correlations Kegg hsa:6196 ENZYME 2.7.11.1

References

UniProt :accession Q15349