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ribosomal S6 kinase-1 (ribosomal protein S6 kinase alpha 1, S6K-alpha 1, 90 kD ribosomal protein S6 kinase 1, p90-RSK 1, RSK-1, pp90RSK1, RPS6KA1)
Function:
- serine/threonine kinase that may play a role in mediating growth-factor & stress induced activation of the transcription factor CREB
- forms a complex with either ERK1 or ERK2 in quiescent cells
- transiently dissociates following mitogenic stimulation activated by multiple phosphorylations on Thr & Ser
- autophosphorylated on Ser-380, as part of the activation process
- activated in cells incubated with insulin, but apparently not a substrate for MAP kinase [2]
Cofactor: Mg+2
Structure:
- belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family, S6 kinase subfamily
- contains 1 AGC-kinase C-terminal domain
- contains 2 protein kinase domains
Interactions
molecular events
General
ribosomal protein S6 kinase
Properties
SIZE: entity length = 735 aa
MW = 83 kD
COMPARTMENT: cytoplasm
STATE: active state
MOTIF: kinase domain
SITE: 62-321
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 68-76
ATP-binding site
NAME: ATP-binding site
SITE: 94-94
aspartate residue {D187}
Ser phosphorylation site {S221}
Thr phosphorylation site {T225}
AGC-kinase C-terminal {322-391}
MOTIF: Thr phosphorylation site {T348}
Thr phosphorylation site {T359}
Ser phosphorylation site {S363}
Ser phosphorylation site {S369}
Ser phosphorylation site {S380}
kinase domain
SITE: 418-675
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 424-432
ATP-binding site
NAME: ATP-binding site
SITE: 447-447
aspartate residue {D535}
Thr phosphorylation site {T573}
Ser phosphorylation site {S732}
Database Correlations
OMIM 601684
UniProt Q15418
PFAM correlations
Kegg hsa:6195
ENZYME 2.7.11.1
References
- UniProt :accession Q15418
- Denton RM.
Insulin signalling: search for the missing links.
Nature. 1990 Nov 22;348(6299):286-7.
PMID: 2250701