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S309 monoclonal antibody
Mechanism of action:
- S309 human monoclonal SARS CoV antibody cross neutralizes SARS CoV-2 via binding to the receptor(ACE2)-binding domain of the spike glyoprotein [1]
- S309 may be useful for prophylaxis in individuals at high risk of exposure or as a post-exposure therapy to limit or treat severe disease [1]
- the question is how does the antibody get onto the epithelial surfaces, especially the upper & lower respiratory tracts
- is it an IgA?
General
monoclonal antibody to spike glycoprotein of SARS-CoV2 (COVID-19)
antiviral agent
References
- Pinto D, Park YJ, Beltramello M et al
Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody.
Nature. May 18, 2020
PMID: 32422645
https://www.nature.com/articles/s41586-020-2349-y