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sphingosine 1-phosphate receptor 4; S1P receptor 4; S1P4; sphingosine 1-phosphate receptor Edg-6; S1P receptor Edg-6; endothelial differentiation G-protein coupled receptor 6 (S1PR4, EDG6)
Function:
- receptor for the lysosphingolipid sphingosine 1-phosphate (S1P)
- may be involved in cell migration processes specific for lymphocytes
Structure: belongs to the G-protein coupled receptor 1 family
Compartment: cell membrane
Expression:
- specifically expressed in fetal & adult lymphoid & hematopoietic tissues,
- expressed in lung, adult & fetal spleen, adult peripheral leukocytes > adult thymus, lymph node, bone marrow, & appendix, fetal liver, thymus, & lung
General
sphingosine 1-phosphate receptor; S1P receptor (S1PR)
Properties
SIZE: MW = 42 kD
entity length = 384 aa
COMPARTMENT: cellular membrane
MOTIF: exoplasmic domain {1-50}
MOTIF: N-glycosylation site {N2}
N-glycosylation site {N30}
transmembrane domain {51-71}
cytoplasmic loop {72-84}
transmembrane domain {85-105}
exoplasmic loop {106-117}
transmembrane domain {118-138}
cytoplasmic loop {139-161}
transmembrane domain {162-182}
exoplasmic loop {183-206}
transmembrane domain {207-227}
cytoplasmic loop {228-252}
transmembrane domain {253-273}
exoplasmic loop {274-288}
transmembrane domain {289-309}
cytoplasmic domain {310-384}
MOTIF: cysteine residue {C323}
MODIFICATION: palmitate
COMPARTMENT: membrane
Database Correlations
OMIM 603751
UniProt O95977
Pfam PF00001
Kegg hsa:8698
References
UniProt :accession O95977