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sphingosine 1-phosphate receptor; S1P receptor (S1PR)
Function:
- receptor for sphingosine 1-phosphate
Related
sphingosine-1-phosphate (S1P)
Specific
sphingosine 1-phosphate receptor 1; G-protein coupled receptor EDG1; S1P receptor 1; S1P1; sphingosine 1-phosphate receptor Edg-1; S1P receptor Edg-1; endothelial differentiation G-protein coupled receptor 1 (S1PR1, CHEDG1, EDG1)
sphingosine 1-phosphate receptor 2; S1P receptor 2; S1P2; sphingosine 1-phosphate receptor Edg-5; S1P receptor Edg-5; endothelial differentiation G-protein coupled receptor 5 (S1PR2, EDG5)
sphingosine 1-phosphate receptor 3; S1P receptor 3; S1P3; sphingosine 1-phosphate receptor Edg-3; S1P receptor Edg-3; endothelial differentiation G-protein coupled receptor 3 (S1PR3, EDG3)
sphingosine 1-phosphate receptor 4; S1P receptor 4; S1P4; sphingosine 1-phosphate receptor Edg-6; S1P receptor Edg-6; endothelial differentiation G-protein coupled receptor 6 (S1PR4, EDG6)
sphingosine 1-phosphate receptor 5 (endothelial differentiation sphingolipid G-protein-coupled receptor 8, S1PR5, EDG8)
General
G-protein coupled receptor; serpentine receptor
Properties
COMPARTMENT: cellular membrane
MOTIF: exoplasmic domain {N-TERMINAL}
ligand-binding site
transmembrane domain {TM1}
transmembrane domain {TM2}
transmembrane domain {TM3}
transmembrane domain {TM4}
transmembrane domain {TM5}
transmembrane domain {TM6}
transmembrane domain {TM7}
transmembrane domain (7)
guanine nucleotide exchange domain
NAME: guanine nucleotide exchange domain
binding site
SITE: C-TERMINAL-CYS
EFFECTOR-BOUND: palmitate
BOUND-VIA: carboxylate
cytoplasmic domain {C-TERMINAL}
References
- Kono M et al,
The sphingosine-1-phosphate receptors S1P1, S1P2, and S1P3
function coordinately during embryonic angiogenesis.
J Biol Chem. 2004 Jul 9;279(28):29367-73
PMID: 15138255
- Seitz G et al,
The Role of Sphingosine 1-Phosphate Receptors in the
Trafficking of Hematopoietic Progenitor Cells
Annals of the New York Academy of Sciences 2006, 1044:84-89
PMID: 15958700