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protein S100-A2; S100 Ca+2-binding protein A2; protein S-100L; CAN19 (S100A2, S100L)

Function: - may act as a modulator against excess Ca+2 accumulation in normal human mammary epithelial cells - may also play a role in suppressing tumor cell growth - binds 2 Ca+2 Structure: - belongs to the S-100 family - contains 2 EF-hand domains Expression: - expressed in a subset of epithelial cells including normal human mammary epithelial cells & keratinocytes - preferentially expressed in normal human mammary epithelial cells as opposed to tumor-derived ones - induced by growth factors in early G1 phase & probably by cell-cycle regulation in S phase - DNA methylation probably plays a direct negative role in suppressing S100L gene expression in tumor cells Pathology: - levels of S100L correlate inversely with breast cancer progression

Related

S100 Ca+2-binding protein

General

S100 Ca+2-binding protein A

Properties

SIZE: entity length = 98 aa MW = 11 kD MOTIF: EF hand SITE: 13-48 MOTIF: Ca+2-binding site SITE: 21-34 EF hand SITE: 51-86 MOTIF: Ca+2-binding site SITE: 64-75

Database Correlations

OMIM 176993 UniProt P29034 Pfam PF01023 Entrez Gene 6273 Kegg hsa:6273

References

  1. UniProt :accession P29034
  2. Entrez Gene :accession 6273