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protein S100-B; S100 Ca+2-binding protein B; S-100 protein subunit beta; S-100 protein beta chain (S100B)
Function:
- weakly binds Ca+2
- binds Zn+2 very tightly
- distinct binding sites with different affinities exist for both Ca+2 & Zn+2 on each monomer
- physiological concentrations of K+ antagonize the binding of both Ca+2 & Zn+2, especially affecting high-affinity Ca+2-binding sites
- binds to & initiates activation of STK38 by releasing autoinhibitory intramolecular interactions within STK38
- the S100B dimer binds two molecules of STK38 (putative)
- the S100B dimer interacts with two molecules of CAPZA1
- in addition to metal-ion binding, role in regulation of protein phosphorylation in brain
Structure:
- dimer of either two alpha chains, or two beta chains, or one alpha & one beta chain.
- belongs to the S-101 family
- contains 2 EF-hand domains
Compartment: cytoplasm, nucleus
Expression:
- predominant among the water-soluble brain proteins
- found in a variety of other tissues
Laboratory:
- S100-beta in CSF
- S100-beta in serum/plasma
Related
S100-beta in serum/plasma
General
Ca+2 binding protein
protein subunit
Properties
SIZE: entity length = 92 aa
MW = 11 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: EF hand
SITE: 13-48
MOTIF: Ca+2-binding site
SITE: 19-32
EF hand
SITE: 49-84
MOTIF: Ca+2-binding site
SITE: 62-73
Database Correlations
OMIM 176990
UniProt P04271
PFAM correlations
Entrez Gene 6285
Kegg hsa:6285
References
- UniProt :accession P04271
- Atlas of Genetics & Cytogenetics in Oncology & Haematology
http://atlasgeneticsoncology.org/genes/S100BID42195ch21q22.html
- UniProt :accession P04271
- Entrez Gene :accession 6285
Component-of
S100 Ca+2-binding protein