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protein S100-A7; S100 Ca+2-binding protein A7; Psoriasin (S100A7, PSOR1, S100A7C)
Function: interacts with RANBP9
Structure:
- belongs to the S-101 family
- contains 2 EF-hand domains
Compartment:
- cytoplasm, secreted
- secreted by a non-classical secretory pathway
Expression:
- fetal ear, skin, & tongue & human cell lines
Pathology:
- highly up-regulated in psoriatic epidermis
- highly expressed in the urine of patients with squamous cell carcinoma of the bladder
Related
S100 Ca+2-binding protein
General
S100 Ca+2-binding protein A
Properties
SIZE: entity length = 101 aa
MW = 11 kD
COMPARTMENT: cytoplasm
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
EF hand
SITE: 13-48
MOTIF: Zn+2-binding site
SITE: 18-18
Zn+2-binding site
SITE: 25-25
cysteine residue {C47}
MODIFICATION: cysteine residue {C96}
EF hand
SITE: 50-85
MOTIF: Ca+2-binding site
SITE: 63-74
Zn+2-binding site
SITE: 87-87
Zn+2-binding site
SITE: 91-91
cysteine residue {C96}
MODIFICATION: cysteine residue {C47}
Database Correlations
OMIM 600353
UniProt P31151
Pfam PF01023
Entrez Gene 6278
Kegg hsa:6278
References
- UniProt :accession P31151
- OMIM :accession 600353
- Entrez Gene :accession 6278
- Burgisser DM et al
Amino acid sequence analysis of human S100A7 (psoriasin) by
tandem mass spectrometry.
Biochem Biophys Res Commun. 1995 Dec 5;217(1):257-63.
PMID: 8526920