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ryanodine receptor (RyR)
Function:
1) Ca+2 channel
2) release Ca+2 from intracellular stores
3) signal transduction
4) excitation-contraction
5) excitation-secretion coupling
6) hysiological modulators:
a) Ca+2
b) kinases
c) phosphatases
d) redox state
e) energy charge, ATP
Structure: tetramer
Expression:
1) RyR1 is expressed mainly skeletal muscle
2) RyR2 is expressed in cardiac muscle
3) RyR3 is expressed in nervous system
Pharmacology:
- pharmacological regulators:
a) caffeine
b) dantrolene
c) ruthenium red
d) heavy metals
e) ryanodine
Related
ryanodine
Specific
ryanodine receptor 1; RYR-1; RyR1; skeletal muscle-type ryanodine receptor; skeletal muscle Ca+2 release channel (RYR1, RYDR)
ryanodine receptor 2; RYR-2; RyR2; hRYR-2; cardiac muscle-type ryanodine receptor; cardiac muscle ryanodine receptor-Ca+2 release channel (RYR2)
Ryanodine receptor 3; RYR-3; RyR3; brain-type ryanodine receptor; brain ryanodine receptor-Ca+2 release channel (RYR3, HBRR)
General
Ca+2 channel
ionotropic receptor
oligomerizing protein
transmembrane 12 protein
Properties
COMPARTMENT: cellular membrane
MOTIF: cytoplasmic domain {N-TERMINAL}
exoplasmic loop
LOOP#: 1
exoplasmic loop
LOOP#: 2
exoplasmic loop
LOOP#: 3
exoplasmic loop
LOOP#: 4
exoplasmic loop
LOOP#: 5
exoplasmic loop
LOOP#: 6
ligand-binding site
membrane region
cytoplasmic domain {C-TERMINAL}
ION-PERMEABILITY: Ca+2
References
- Butanda-Ochoa A, Hojer G, Morales-Tlalpan V, Diaz-Munoz M.
Recognition and activation of ryanodine receptors by purines.
Curr Med Chem. 2006;13(6):647-57. Review.
PMID: 16529557
- Wikipedia; Note: Ryanodine receptor entry
http://en.wikipedia.org/wiki/Ryanodine_receptor