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retinoic acid receptor RXR-gamma; retinoid X receptor gamma; nuclear receptor subfamily 2 group B member 3 (RXRG, NR2B3)
Function:
- nuclear hormone receptor
- role in retinoic acid response pathway
- binds 9-cis retinoic acid (9C-RA)
Structure:
- composed of three domains:
a) modulating N-terminal domain
b) DNA-binding domain
c) C-terminal steroid-binding domain
- belongs to the nuclear hormone receptor family, NR2 subfamily
- contains 1 nuclear receptor DNA-binding domain
Compartment: nucleus (putative)
General
retinoid X receptor (RXR)
Properties
SIZE: entity length = 463 aa
MW = 51 kD
COMPARTMENT: cell nucleus
MOTIF: Modulating {1-138}
DNA-binding motif
SITE: 136-211
MOTIF: Zn finger C4-type
SITE: 139-159
EFFECTOR-BOUND: Zn+2
Zn finger C4-type
SITE: 175-199
EFFECTOR-BOUND: Zn+2
Hinge {205-260}
binding site
SITE: 261-463
FOR-BINDING-OF: ligand
Database Correlations
OMIM 180247
UniProt P48443
PFAM correlations
Entrez Gene 6258
References
- Green S.
Nuclear hormone receptors. Promiscuous liaisons.
Nature. 1993 Feb 18;361(6413):590-1.
PMID: 8382343
- UniProt :accession P48443