Search
retinoic acid receptor RXR-beta; retinoid X receptor beta; nuclear receptor subfamily 2 group B member 2 (RXRB, NR2B2)
Function:
- nuclear hormone receptor
- role in retinoic acid response pathway
- binds 9-cis retinoic acid (9C-RA)
Structure:
- composed of three domains:
a) modulating N-terminal domain
b) DNA-binding domain
c) C-terminal steroid-binding domain
- belongs to the nuclear hormone receptor family, NR2 subfamily
- contains 1 nuclear receptor DNA-binding domain
Compartment: nucleus
Expression: expressed in a variety of tumor cell lines
General
retinoid X receptor (RXR)
Properties
SIZE: entity length = 533 aa
MW = 57 kD
COMPARTMENT: cell nucleus
MOTIF: Modulating {1-204}
MOTIF: proline-rich region
SITE: 61-198
MOTIF: proline residue (SEVERAL)
DNA-binding motif
SITE: 205-270
MOTIF: Zn finger C4-type
SITE: 205-225
EFFECTOR-BOUND: Zn+2
Zn finger C4-type
SITE: 241-265
EFFECTOR-BOUND: Zn+2
Hinge {271-330}
binding site
SITE: 331-533
FOR-BINDING-OF: ligand
Database Correlations
OMIM 180246
UniProt P28702
PFAM correlations
Entrez Gene 6257
Kegg hsa:6257
References
- Sporn MB, Roberts AB.
Interactions of retinoids and transforming growth factor-beta
in regulation of cell differentiation and proliferation.
Mol Endocrinol. 1991 Jan;5(1):3-7. Review.
PMID: 2017191
- Green S.
Nuclear hormone receptors. Promiscuous liaisons.
Nature. 1993 Feb 18;361(6413):590-1.
PMID: 8382343
- UniProt :accession P28702