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retinoic acid receptor RXR-alpha; retinoid X receptor alpha; nuclear receptor subfamily 2 group B member 1 (RXRA, NR2B1)
Function:
- nuclear hormone receptor
- involved in the retinoic acid response pathway
- binds 9-cis retinoic acid (9C-RA)
- ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer
- sumoylated on Lys-108; sumoylation negatively regulates transcriptional activity
- desumoylated specifically by SENP6
- homodimer or forms a heterodimer with PPAR-gamma (adipocyte-specific transcription factor ARF6)
- interaction with NCOA3 & NCOA6 coactivators, leads to transcription of target genes
- interacts with FAM120B (putative)
- interacts with SFPQ
- interacts with HCV core protein
- interacts with PELP1
- interacts with SENP6
- interacts with DNTTIP2
- interacts with RNF8
Structure:
- composed of three domains:
a) modulating N-terminal domain
b) DNA-binding domain
c) C-terminal steroid-binding domain
- belongs to the nuclear hormone receptor family, NR2 subfamily
- contains 1 nuclear receptor DNA-binding domain
Compartment: nucleus
Expression:
- highly expressed in liver
- also found in lung, kidney & heart
General
retinoid X receptor (RXR)
Properties
SIZE: entity length = 462 aa
MW = 51 kD
COMPARTMENT: cell nucleus
MOTIF: Modulating {1-134}
DNA-binding motif
SITE: 135-200
MOTIF: Zn finger C4-type
SITE: 135-155
EFFECTOR-BOUND: Zn+2
Zn finger C4-type
SITE: 171-195
EFFECTOR-BOUND: Zn+2
Hinge {201-224}
binding site
SITE: 225-462
FOR-BINDING-OF: ligand
Database Correlations
OMIM 180245
UniProt P19793
PFAM correlations
Entrez Gene 6256
Kegg hsa:6256
References
- Sporn MB, Roberts AB.
Interactions of retinoids and transforming growth factor-beta
in regulation of cell differentiation and proliferation.
Mol Endocrinol. 1991 Jan;5(1):3-7. Review.
PMID: 2017191
- Green S.
Nuclear hormone receptors. Promiscuous liaisons.
Nature. 1993 Feb 18;361(6413):590-1.
PMID: 8382343
- Wikipedia; Note: retinoid X receptor entry
http://en.wikipedia.org/wiki/retinoid_X_receptor
- UniProt :accession P19793