RuvB-like 2 (48-kD TATA box-binding protein-interacting protein, 48 kD TBP-interacting protein, TIP49b, repressing pontin 52, Reptin 52, 51 kD erythrocyte cytosolic protein, ECP-51, TIP60-associated protein 54-beta, TAP54-beta, RUVBL2, TIP48, TIP49B, CGI-46)

Function: - component of the NuA4 histone acetyltransferase complex - possesses single-stranded DNA-stimulated ATPase & ATP- dependent DNA helicase (5' to 3') activity - NuA4 complex ATPase & helicase activities contributed by association of RUVBL1 & RUVBL2 with EP400 - RUVBL2 plays an essential role in oncogenic transformation by MYC & also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex - may also inhibit the transcriptional activity of ATF2 - forms a multimeric complex with RUVBL1 - interacts with the transcriptional activation domain of MYC - interacts With ATF2 - component of the RNA polymerase 2 holoenzyme complex - may also act to bridge the LEF1/TCF1-CTNNB1 complex & TBP - RUVBL2 interacts with EP400 component of a NuA4-related complex which contains EP400, TRRAP/PAF400, SRCAP, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, actin, ACTL6A/BAF53A, TCFL1/YL1 & YEATS4/GAS41 - interacts with NPAT - phosphorylated upon DNA damage, probably by ATM or ATR Structure: - C-terminal domain is required for association with ATF2 - belongs to the ruvB family Compartment: - nuclear matrix, nucleus, nucleoplasm cytoplasm, membrane - mainly localized in the nucleus, - associated with nuclear matrix or in the nuclear cytosol; also present in cytoplasm & associated with cell membranes Expression: - ubiquitously expressed - highly expressed in testis & thymus

General

phosphoprotein protein subunit

Properties

SIZE: entity length = 463 aa MW = 51 kD COMPARTMENT: cytoplasm cell nucleus MOTIF: ATP-binding site NAME: ATP-binding site SITE: 77-84 Ser phosphorylation site {S220}

Database Correlations

OMIM 604788 UniProt Q9Y230 PFAM correlations Kegg hsa:1085

References

UniProt :accession Q9Y230