RUN domain-containing protein 3B (rap2-binding protein 9, rap2-interacting protein 9, RUNDC3B, RPIB9, RPIP9)

interacts with RAP2A (putative) Structure: - belongs to the RUNDC3 family - contains 1 RUN domain Alternative splicing: named isoforms=4 Expression: - isoform 2 is expressed at high levels in brain, thymus, ovary, testis, leukocyte, liver, small intestine & prostate - isoform 1 is expressed in the brain, testis & adrenal gland Pathology: - activated in tumorigenic breast cancer cell lines & in the primary tumor of breast cancer patients - activation correlates with metastatic lymph node invasion & can be detected in metastatic epithelial cells from the lymph nodes & in the bone marrow of patients

Properties

SIZE: entity length = 473 aa MW = 53 kD MOTIF: glycine-rich region {14-20} RUN {57-206} coiled coil {317-342}

Database Correlations

UniProt Q96NL0 Pfam PF02759 Kegg hsa:1546

References

UniProt :accession Q96NL0