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RUN & SH3 domain-containing protein 1 (new molecule containing SH3 at the carboxy-terminus, Nesca, RUSC1, NESCA)
Function:
- putative signaling adapter
- role in neuronal differentiation
- role in regulation of NGF-dependent neurite outgrowth
- role in signaling pathways regulated by prolonged activation of MAPK (putative)
- phosphorylated on Ser following nuclear translocation
Structure:
- RUN domain is necessary for NGF induced nuclear redistribution
- contains 1 RUN domain
- contains 1 SH3 domain
Compartment:
- cytoplasm, nucleus
- translocated to nuclear envelope upon stimulation with NGF
Alternative splicing: named isoforms=2
Expression: predominantly expressed in brain
General
phosphoprotein
Properties
SIZE: MW = 96 kD
entity length = 902 aa
COMPARTMENT: cytoplasm
nuclear membrane
MOTIF: RUN {522-666}
src homology 3 [SH3] domain
SITE: 844-902
Database Correlations
UniProt Q9BVN2
PFAM correlations
References
UniProt :accession Q9BVN2