radical S-adenosyl methionine domain-containing protein 2 (virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible, viperin, cytomegalovirus-induced gene 5 protein, RSAD2, CIG5)

Function: - role in antiviral defense - inhibits infection by human cytomegalovirus, down-regulating expression of a number of viral proteins including glycoprotein B, pp28 & pp65 - inhibits replication of hepatitis C virus Cofactor: - binds 1 4Fe-4S cluster - cluster is coordinated with 3 cysteines & an exchangeable S-adenosyl-L-methionine Structure: belongs to the RSAD2 family Compartment: - endoplasmic reticulum, Golgi apparatus - probably associates with the cytosolic side of the endoplasmic reticulum - infection with human cytomegalovirus (HCMV) causes relocation to the Golgi & to cytoplasmic vacuoles which also contain HCMV proteins glycoprotein B & pp28 Expression: - induced by LPS, interferon alpha &, to a lesser extent, interferon gamma - little or no induction by interferon gamma is observed in monocytic cell lines - induced by infection with human cytomegalovirus (HMCV), hepatitis C virus, yellow fever virus & Sendai virus - induction by HMCV is mediated by glycoprotein B Pathology: - expressed in the endothelium of atherosclerotic arteries but not in normal arteries (at protein level)

Properties

GENERAL: uncharacterized protein SIZE: entity length = 361 aa MW = 42 kD FORM: radical S-adenosyl methionine domain-containing protein 2 MOTIF: cofactor-binding site [83-83] COFACTOR-BOUND: iron sulfur [FeS] cluster cofactor-binding site [87-87] COFACTOR-BOUND: iron sulfur [FeS] cluster cofactor-binding site [90-90] COFACTOR-BOUND: iron sulfur [FeS] cluster

Database Correlations

OMIM 607810 UniProt Q8WXG1 Pfam PF04055

References

UniProt :accession Q8WXG1