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Ras-related protein R-Ras2; Ras-like protein TC21; teratocarcinoma oncogene (RRAS2, TC21)
Function:
- plasma membrane-associated GTP-binding protein with GTPase activity
- might transduce growth inhibitory signals across the cell membrane, via an effector shared with Ras proteins; effects are antagonistic to Ras proteins
- may be post-translationally modified by both palmitoylation & polyisoprenylation
Structure: belongs to the small GTPase superfamily, Ras family
Compartment:
- cell membrane; lipid-anchor; cytoplasmic side (putative)
- inner surface of plasma membrane possibly with attachment requiring farnesylation of the C-terminal Cys (Caax motif)
Expression:
- ubiquitously present in all tissues examined
- highest levels in heart, placenta, & skeletal muscle
- moderate levels in lung & liver
- low levels in brain, kidney, & pancreas
Pathology: defects in RRAS2 may be a cause of ovarian tumors
General
ras subfamily protein
Properties
SIZE: entity length = 204 aa
MW = 23 kD
COMPARTMENT: cytoplasm
MOTIF: GTP-binding site
SITE: 21-28
Effector region {43-51}
GTP-binding site
SITE: 68-72
GTP-binding site
SITE: 127-130
Ser phosphorylation site {S186}
CaaX motif
SITE: C-TERMINUS
QUALITIES: AAX-TRUNCATED
CARBOXYMETHYLATED
EFFECTOR-BOUND: farnesyl
BOUND-VIA: cysteine residue
Database Correlations
OMIM 600098
MORBIDMAP 600098
UniProt P62070
Pfam PF00071
Entrez Gene 22800
Kegg hsa:22800
References
- UniProt :accession P62070
- Kahn RA, Der CJ, Bokoch GM.
The ras superfamily of GTP-binding proteins: guidelines on
nomenclature.
FASEB J. 1992 May;6(8):2512-3.
PMID: 1592203