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Rotavirus

Epidemiology: - viral shedding detected for up to 35 days from onset of symptoms [3] - % of stool samples has declined from after introduction of the rotavirus vaccine [4] Pathology: - viral enteritis (rotavirus enteritis) in children & elderly (outbreaks in retirement communities) Laboratory: - rotovirus antigen in stool - adenovirus+rotavirus Ag in stool - adenovirus+rotavirus in stool - rotavirus serology - rotavirus RNA - rotavirus A RNA - rotavirus A VP4 gene - rotavirus A VP7 gene - rotavirus B RNA - rotavirus B VP7 gene - rotavirus C RNA - rotavirus C VP7 gene - rotavirus A VP6 capsid protein in specimen - rotavirus in stool by electron microscopy - rotavirus A in specimen - rotavirus C in specimen - rotavirus identified by culture

Related

rotavirus enteritis rotavirus RNA rotavirus vaccine (Rotashield, Rotateq, Rotarix)

General

Reoviridae

Properties

KINGDOM: virus GENOME-TYPE: RNA DOUBLE-STRANDED GENOME-SIZE: 16-27 kB ENVELOPE: NONE CAPSID-SYMMETRY: ICOSOHEDRAL

References

  1. Clinical Guide to Laboratory Tests, 3rd ed. Teitz ed., W.B. Saunders, 1995
  2. Parashar UD, Alexander JP, Glass RI; Advisory Committee on Immunization Practices (ACIP), Centers for Disease Control and Prevention (CDC). Prevention of rotavirus gastroenteritis among infants and children. Recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep. 2006 Aug 11;55(RR-12):1-13. PMID: 16902398 http://www.cdc.gov/mmwr/preview/mmwrhtml/rr5512a1.htm
  3. Cardemil CV et al. Two rotavirus outbreaks caused by genotype G2P[4] at large retirement communities: Cohort studies. Ann Intern Med 2012 Nov 6; 157:621 PMID: 23128862
  4. Aliabadi N et al Sustained Decrease in Laboratory Detection of Rotavirus after Implementation of Routine Vaccination - United States, 2000- 2014. MMWR Weekly. April 10, 2015 / 64(13);337-342 http://www.cdc.gov/mmwr/preview/mmwrhtml/mm6413a1.htm