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peptidyl-prolyl cis/trans isomerase (PPIase) or rotamase
Classification:
classified into 3 families:
- cyclophilins
- FK506 binding proteins
- parvulins (includes parvulins & pin1 protein)
Function:
- accelerates the folding of proteins
- catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Specific
immunophilins (includes cyclophilins & FK506 binding proteins)
peptidyl-prolyl cis-trans isomerase A-like 4C; PPIase A-like 4C (PPIAL4C)
peptidyl-prolyl cis-trans isomerase A-like 4D; PPIase A-like 4D (PPIAL4D)
peptidyl-prolyl cis-trans isomerase A-like 4E; PPIase A-like 4E (PPIAL4E)
peptidyl-prolyl cis-trans isomerase A-like 4F; PPIase A-like 4F (PPIAL4F)
peptidyl-prolyl cis-trans isomerase A-like 4G; PPIase A-like 4G; peptidylprolyl cis-trans isomerase A-like 4 (PPIAL4G)
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1; peptidyl-prolyl cis-trans isomerase Pin1; PPIase Pin1; Rotamase Pin1 (PIN1)
peptidyl-prolyl cis-trans isomerase-like 1 (PPIase, rotamase, PPIL1, CYPL1, CGI-124, UNQ2425/PRO4984)
peptidyl-prolyl cis-trans isomerase-like 4 (PPIase, Rotamase, cyclophilin-like protein PPIL4, PPIL4)
peptidylprolyl cis-trans isomerase A-like 4B (PPIase A-like 4B, chromosome 1-amplified sequence 2, COAS-2, cyclophilin homolog overexpressed in liver cancer, PPIAL4B COAS2)
peptidylprolyl isomerase domain and WD repeat-containing protein 1 (PPWD1, KIAA0073)
General
isomerase
Properties
MOTIF: active site
References
- Lu KP, Liou YC, Zhou XZ.
Pinning down proline-directed phosphorylation signaling.
Trends Cell Biol. 2002 Apr;12(4):164-72. Review.
PMID: 11978535
- Tai PK et al
Association of a 59-kilodalton immunophilin with the
glucocorticoid receptor complex.
Science 256:1315 1992
PMID: 1376003