ropporin-1A (rhophilin-associated protein 1A, cancer/testis antigen 91, CT91, ROPN1 ROPN1A)

Function: - interacts with AKAP3 & RHPN1 - may interact with SPA17 Structure: - homodimer - RIIa domain mediates interaction with AKAP3 - belongs to the ropporin family - contains 1 RIIa domain Compartment: - in the sperm tail, found in the principal piece & in the cytoplasmic droplet located at the distal end of the midpiece. - inner surface of the fibrous sheath Alternative splicing: named isoforms=2 Expression: - testis specific in adult - expressed in fetal liver Pathology: - overexpressed in hematologic tumor cells Miscellaneous: The name 'ropporin' comes from the Japanese word 'oppo' which means 'tail'

Properties

GENERAL: uncharacterized protein SIZE: entity length = 212 aa MW = 24 kD FORM: ropporin-1A MOTIF: RIIa {12-49} RHPN1 interaction {209-212}

Database Correlations

UniProt Q9HAT0 Pfam PF02197

References

UniProt :accession Q9HAT0