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role of IL-6 in multiple myeloma
Role of IL-6:
1) IL-6 is essential for survival & proliferation of myeloma cells which express receptors IL-6 receptors
2) IL-6 prevents spontaneous & dexamethasone-induced apoptosis of myeloma cells
3) serum IL-6 is increased in patients with myeloma, thought to be produced largely by stromal & bone cells within the marrow
4) myeloma cells shed the soluble form of the IL-6 receptor alpha which can apparently amplify response of myeloma cells to IL-6
5) soluble IL-6 receptor alpha is present in serum of patients with myeloma, especially increased in patients with poor prognosis
6) IL-6, soluble IL-6 receptor alpha & IL-1 beta activate osteoclasts & thus provoke bone reabsorption in myeloma
Related
interleukin-6; IL-6; B-cell stimulatory factor 2; BSF-2; CTL differentiation factor; CDF; hybridoma growth factor; interferon beta-2; IFN-beta-2 (IL6, IFNB2)
multiple myeloma; plasmacytoma/plasma cell myeloma