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nuclear receptor subfamily 4 group A member 2; orphan nuclear receptor NURR1; immediate-early response protein NOT; transcriptionally-inducible nuclear receptor (NR4A2, NOT, NURR1, TINUR)

Function: - probable nuclear receptor - may function as a general coactivator of gene transcription - detection of the protein in the brain, indicates that it is not mandatorily associated with cell cycle progression - required for development of midbrain dopaminergic neurons - can interact with DNA as monomer & forms heterodimers with RXR which binds to similar response elements as RAR-RXR Structure: - belongs to the nuclear hormone receptor family, NR4 subfamily - contains 1 nuclear receptor DNA-binding domain Compartment: nucleus (probable) Expression: - expressed in a number of cell lines of T-cell, B-cell & fibroblast origin - strong expression in brain tissue - expressed in neurons in substantia nigra pars compacta & ventral tegmentum - encoded by immediate early gene - rapidly & only very transiently expressed after cell activation, during the G0-G1 transition of the cell cycle

General

immediate early response protein nuclear hormone receptor NR4 subfamily phosphoprotein zinc finger protein

Properties

SIZE: entity length = 598 aa MW = 67 kD COMPARTMENT: cell nucleus MOTIF: glutamine-rich region {80-138} MOTIF: glutamine residue (SEVERAL) proline-rich region SITE: 127-233 MOTIF: proline residue (SEVERAL) Ser phosphorylation site {S181} DNA-binding motif SITE: 260-335 MOTIF: Zn finger C4-type SITE: 263-283 EFFECTOR-BOUND: Zn+2 Zn finger C4-type SITE: 299-323 EFFECTOR-BOUND: Zn+2 proline-rich region SITE: 346-391 MOTIF: proline residue (SEVERAL) binding site SITE: 409-459 FOR-BINDING-OF: ligand

Database Correlations

OMIM 601828 UniProt P43354 PFAM correlations Entrez Gene 4929 Kegg hsa:4929

References

  1. UniProt :accession P43354
  2. GeneReviews http://www.ncbi.nlm.nih.gov/sites/genetests/lab/gene/NR4A2
  3. Zetterstrom RH et al Dopamine neuron agenesis in Nurr1-deficient mice. Science 276:248-9 1997 PMID: 9092472
  4. Zetterstrom RH et al Cellular expression of the immediate early transcription factors Nurr1 and NGFI-B suggests a gene regulatory role in several brain regions including the nigrostriatal dopamine system. Mol Brain Res 41:111-20 1996 PMID: 8883941