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RNP Ab in serum

Etiology: - systemic lupus erythematosus (46%) - scleroderma - rheumatoid arthritis - discoid lupus - Sjogren's syndrome - mixed connective tissue disease (high titer) Reference values: - Normal: negative for antibodies to RNP [<20 EU/mL] Interpretation: - < 20 EU/mL: negative for antibodies to RNP - 20-25 EU/mL: equivocal for antibodies to RNP - >25 EU/mL: positive for antibodies to RNP Clinical significance: Antibodies to Smith antigen (anti-Sm Ab) & to U1 RNP (anti-U1 RNP Ab) are associated with antibodies to small nuclear RNP associated with the spliceosome.

Related

ribonucleoprotein

Specific

fibrillarin (U3 RNP) Ab in serum RNP 52kD Ab in serum RNP 63kD Ab in serum RNP IgG in serum Sm (Smith) Ab in serum SM+RNP Ab in serum U1 RNP Ab in serum U2 RNP Ab in serum

General

RNP Ab in body fluid

References

  1. Medical Knowledge Self Assessment Program (MKSAP) 16, American College of Physicians, Philadelphia 2012

Component-of

extractable nuclear antigen (ENA) Ab Smith antigen (Sm) & ibonucleoprotein (RNP) Ab in serum