E3 ubiquitin-protein ligase RNF5 (HsRma1, RING finger protein 5, protein G16, RNF5, G16, NG2, RMA1)

Function: 1) E2-dependent E3 ubiquitin-protein ligase activity 2) may function together with E2 ubiquitin-conjugating enzymes UBE2D1/UBCH5A & UBE2D2/UBC4 3) mediates ubiquitination of PXN/paxillin 4) may be involved in regulation of cell motility & localization of PXN/paxillin 5) interacts with PXN Structure: - contains 1 RING-type zinc finger Compartment: - membrane, plasma membrane (majority) - cytoplasmic organelles Expression: widely expressed Pathology: 1) interacts with Salmonella typhimurium sopA - mediates ubiquitination of sopA

General

membrane protein ring finger protein E3 ubiquitin ligase; ubiquitin-ligating enzyme E3; N end-recognizing protein

Properties

SIZE: MW = 20 kD entity length = 180 aa COMPARTMENT: cytoplasm MOTIF: RING-finger {27-68} EFFECTOR-BOUND: Zn+2 FOR-BINDING-OF: DNA motif transmembrane domain {118-138} transmembrane domain {160-180}

Database Correlations

OMIM 602677 UniProt Q99942 Pfam PF00097

References

UniProt :accession Q99942