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RING finger protein 14; E3 ubiquitin-protein ligase RNF14; androgen receptor-associated protein 54; HFB30; triad2 protein (RNF14, ARA54, HRIHFB2038)
Function:
- may play role as an E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes & transfers it to substrates, perhaps nuclear proteins
- may play role as a coactivator for androgen- &, to a lesser extent, progesterone-dependent transcription
- protein modification; protein ubiquitination
- RING-type Zn+2 finger-dependent & UBE2E2-dependent autoubiquitination
- interacts with the ubiquitin-conjugating enzymes UBE2E1 & UBE2E2
- interacts with AR/androgen receptor
- testosterone- & RNF6-regulated
- promotes AR transcriptional activity
Structure:
- the N-terminal destruction box (D-box) acts as a recognition signal for degradation via the ubiquitin-proteasome pathway (putative)
- the RING-type Zn+2 finger is essential for the interaction with UBE2E2
- belongs to the RBR family, RNF14 subfamily
- contains 1 IBR-type Zn+2 finger
- contains 2 RING-type Zn+2 fingers
- contains 1 RWD domain
- lacks His in the RING-type domain 2, one of the conserved features of the family
Compartment: cytoplasm. nucleus
Expression: widely expressed
General
phosphoprotein
ring finger protein
E3 ubiquitin ligase; ubiquitin-ligating enzyme E3; N end-recognizing protein
Properties
SIZE: entity length = 474 aa
MW = 54 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: RWD {11-137}
MOTIF: ubiquitination site (destruction box, D-box)
SITE: 37-45
FOR-BINDING-OF: ubiquitin
RING-finger {220-270}
EFFECTOR-BOUND: Zn+2
FOR-BINDING-OF: DNA motif
Zinc finger
NAME: Zinc finger
SITE: 289-350
EFFECTOR-BOUND: Zn+2
MOTIF: Ser phosphorylation site {S348}
coiled coil {351-395}
androgen receptor interaction {361-474}
MOTIF: RING-finger {404-433}
EFFECTOR-BOUND: Zn+2
FOR-BINDING-OF: DNA motif
Database Correlations
OMIM 605675
UniProt Q9UBS8
PFAM correlations
Entrez Gene 9604
Kegg hsa:9604
References
UniProt :accession Q9UBS8