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rhoN protein (Rho-related GTP-binding protein RhoN, Rho7, Rnd2)
Function:
- may be specifically involved in neuronal & hepatic functions
- C3 toxin-insensitive member of the Rho subfamily
- interacts with the Rho-GAP domain of RACGAP1
- interacts with UBXD5
Structure: belongs to the small GTPase superfamily, Rho family
Compartment:
- cell membrane; lipid-anchor; cytoplasmic side (putative
- colocalizes with RACGAP1 in Golgi-derived proacrosomal vesicles & the acrosome
Expression: highly expressed in testis
General
rho subfamily protein
Properties
SIZE: entity length = 227 aa
MW = 25 kD
COMPARTMENT: cytoplasm
golgi
MOTIF: GTP-binding site
SITE: 14-21
Effector region {36-44}
GTP-binding site
SITE: 61-65
GTP-binding site
SITE: 119-122
CaaX motif
SITE: C-TERMINUS
QUALITIES: AAX-TRUNCATED
CARBOXYMETHYLATED
EFFECTOR-BOUND: geranylgeranyl{C20}
BOUND-VIA: cysteine residue
Database Correlations
OMIM 601555
UniProt P52198
Pfam PF00071
Entrez Gene 8153
Kegg hsa:8153
References
- UniProt :accession P52198
- OMIM :accession 601555
- Entrez Gene :accession 8153