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GTP-binding protein Rit2 (Ras-like protein expressed in neurons, Ras-like without CAAX protein 2, RIT2, RIN, ROC2)
Function:
- binds & exchanges GTP & GDP (putative)
- rapid uncatalyzed guanine nucleotide dissociation rates, which are much faster than those of most Ras subfamily members (putative)
- interacts with MLLT4, the C-terminal domain of RALGDS & RLF, but not with RIN1 & PIK3CA
- RLF binds exclusively to the active GTP-bound form (putative)
- binds calmodulin
Structure: belongs to the small GTPase superfamily, Ras family
Compartment: cell membrane
Alternative splicing: named isoforms=2
Expression: neuron-specific
General
ras subfamily protein
Properties
SIZE: MW = 25 kD
entity length = 217 aa
COMPARTMENT: plasma membrane
CELL: unspecified cell type
ORGANISM: mammal
MOTIF: GTP-binding site
SITE: 27-34
GTP-binding site
SITE: 74-78
GTP-binding site
SITE: 133-136
Database Correlations
UniProt Q99578
Pfam PF00071
References
UniProt :accession Q99578