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ristocetin cofactor activity

Clinical significance: - ristocetin-induced agglutination of platelets requires a cofactor found in serum - that cofactor is von-Willebrand's factor (vWF) Decreases: - von-Willebrand's disease Methods: - freshly washed or formalin fixed aggregation of normal platelets induced by ristocetin in the presence of patient serum is generally considered a sensitive indicator of vWF functional activity - less sensitive techniques involve platelet aggregation studies after direct addition of ristocetin to patient platelet-rich plasma. Specimen: plasma

Related

ristocetin von Willebrand factor; vWF; ristocetin cofactor; factor VIII related antigen; contains: von Willebrand antigen 2 (VWF, F8VWF)

General

von Willebrand factor activity in plasma

References

  1. Clinical Diagnosis & Management by Laboratory Methods, 19th ed. J.B. Henry (ed), W.B. Saunders Co., Philadelphia, PA. 1996, pg 732
  2. Panel of 4 tests Laboratory Test Directory ARUP: 30002
  3. Panel of 3 tests Laboratory Test Directory ARUP: 30125
  4. Von Willebrand Factor, Activity (RCF) Laboratory Test Directory ARUP: 30250
  5. Mini Panel of 2 tests: Von Willebrand Factor, Activity (RCF) . Von Willebrand Factor, Antigen Laboratory Test Directory ARUP: 30284
  6. Panel of 3 tests Laboratory Test Directory ARUP: 2003387
  7. Panel of 7 tests Laboratory Test Directory ARUP: 2003417

Component-of

vWf ristocetin cofactor/vWf Ag in plasma