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ristocetin

An antibiotic produced by fermentation of Amycolatopis orientalis subspecies lurida, comprising two substances ristocetin A & ristocetin B. Ristocetin-induced agglutination of platelets requires a cofactor found in serum. That cofactor is von-Willebrand's factor (vWF). As a pharmaceutical agent: Indications: -> Staphylococcal & Enterococcal infections refractory to other antibiotics Antimicrobial activity: Gram positive - Staphylococcus - Enterococcus

Related

ristocetin cofactor activity von Willebrand factor; vWF; ristocetin cofactor; factor VIII related antigen; contains: von Willebrand antigen 2 (VWF, F8VWF)

General

antibiotic combination

References

  1. Clinical Diagnosis & Management by Laboratory Methods, 19th ed. J.B. Henry (ed), W.B. Saunders Co., Philadelphia, PA. 1996, pg 732
  2. Stedman's Medical Dictionary 27th ed, Williams & Wilkins, Baltimore, 1999