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RAD50-interacting protein 1; RAD50 interactor 1; HsRINT-1; RINT-1 (RINT1)
Function:
- role in membrane traffic between endoplasmic reticulum & Golgi
- cell cycle checkpoint control (putative)
- telomere length control
- interacts with RAD50 during late S phase & G2/M phase.
- component of a SNARE complex consisting of STX18, USE1L, BNIP1/SEC20L, & SEC22B
- within the SNARE complex, interacts with BNIP1/SEC20L
- interacts with ZW10
- interacts with RBL2, preferentially with active, hypophosphorylated form
Structure:
- belongs to the RINT1 family
- contains 1 RINT1/TIP20 domain
Compartment:
- cytoplasm, endoplasmic reticulum, peripheral membrane
Expression: expressed throughout the cell cycle
Related
DNA repair protein RAD50; hRAD50 (RAD50)
General
other protein
Properties
SIZE: entity length = 792 aa
MW = 91 kD
COMPARTMENT: cytoplasm
endoplasmic reticulum
MOTIF: coiled coil {103-124}
RINT1/TIP20 {220-792}
Database Correlations
OMIM 610089
UniProt Q6NUQ1
Pfam PF04437
Entrez Gene 60561
Kegg hsa:60561
References
UniProt :accession Q6NUQ1
Component-of
SNARE-like complex